Next-generation sequencing reveals novel mutations in a collision tumor of glioblastoma and meningioma

Next-generation sequencing reveals novel mutations in a collision tumor of glioblastoma and meningioma

Blog Article

Primary intracranial collision tumors are rare in Booster Seats patients without predisposing factors.We report such a case in a 42-year-old female who presented with headaches and altered mental status.Imaging revealed a single heterogeneous, rim-enhancing lesion in the left parieto-occipital periventricular region, involving the corpus callosum.

Stereotactic biopsy demonstrated glioblastoma.Subsequent tumor resection showed histologic evidence of glioblastoma and meningioma.Next-generation sequencing was performed on both tumor components.

The glioblastoma exhibited a CDKN2A Sound meters homozygous deletion and novel missense mutations in TAF1L and CSMD3, while no definitive genetic alterations were identified in the meningioma.Next-generation sequencing may yield insight into molecular drivers of intracranial collision tumors and aid in identifying future therapeutic targets.